Eutectic Mixtures in Pharmaceuticals: Strategies for Enhancing Drug Solubility and Bioavailability

Editors: Kamlesh Kumari, Madhur Babu Singh, Pallavi Jain, Prashant Singh

Eutectic Mixtures in Pharmaceuticals: Strategies for Enhancing Drug Solubility and Bioavailability

ISBN: 979-8-89881-868-5
eISBN: 979-8-89881-867-8 (Online)

Introduction

This book offers a multidisciplinary exploration of eutectic mixtures (EMs) as a strategy for overcoming poor aqueous solubility, dissolution and bioavailability of active pharmaceutical ingredients (APIs). Beginning with foundational pharmaceutical concepts, it progresses through the physicochemical, thermodynamic and solid-state fundamentals of EMs, their preparation and characterization, computational prediction of solubility behavior and applications across oral, topical, transdermal and advanced drug delivery systems.


Key Features

  • - Comprehensive coverage from drug fundamentals to industrial applications of EMs.
  • - Preparation methods: mechanical, solvent-assisted, fusion and innovative techniques.
  • - Analytical and characterization tools (DSC, TGA, PXRD, FTIR, Raman spectroscopy, microscopy).
  • - Computational approaches for predicting solubility and EM behavior.
  • - Experimental evaluation of drug release, toxicity and safety.
  • - Insights into drug coformer selection strategies.

Target Readership :

Undergraduates, postgraduates, research scholars and professors/researchers.

Foreword

Over the past few decades, pharmaceutical sciences have undergone remarkable advancements in drug discovery and development. Despite these developments, the persistent challenge of poor aqueous solubility among active pharmaceutical ingredients (APIs) continues to hinder the efficacy of numerous promising therapeutic agents. In an era where targeted medicine and rapid therapeutic delivery are increasingly prevalent, identifying practical, scalable solutions to enhance drug solubility and bioavailability remains a top priority for researchers and industry professionals.

This book, titled Eutectic Mixtures in Pharmaceuticals: Strategies for Enhancing Drug Solubility and Bioavailability, arrives at a timely juncture. This book offers a comprehensive and timely exploration of eutectic mixtures, an underutilized yet highly promising approach to overcoming solubility challenges. By seamlessly integrating theoretical insights, practical strategies, and real-world applications, the authors bridge the gap between fundamental science and pharmaceutical innovation.

The work on the eutectic mixture is in-depth, clear, and multidisciplinary. A collaborative effort by experts in chemistry, pharmaceutical sciences, material science, and biomedical engineering, the book reflects the interconnected nature of modern drug formulation. Each chapter is thoughtfully crafted to guide readers from foundational principles to advanced applications, making it a valuable resource for both newcomers and professionals. The inclusion of case studies, computational approaches, and industrial perspectives ensures that the book is not just academic but also focused on the realities of pharmaceutical development. It addresses not only the potential of eutectic mixtures but also the challenges and limitations that must be navigated to bring these innovations from bench to bedside.

I commend the authors of the chapters and the editors for their dedication to bringing together this much-needed volume. I am confident that this book will serve as a reference for educators, students, and innovators committed to advancing drug formulation.

Nagendra K. Kaushik
Department of Electrical and Biological Physics,
PBRC, Kwangwoon University, Seoul,
South Korea