Eutectic Mixtures in Pharmaceuticals: Strategies for Enhancing Drug Solubility and Bioavailability

Editors: Kamlesh Kumari, Madhur Babu Singh, Pallavi Jain, Prashant Singh

Eutectic Mixtures in Pharmaceuticals: Strategies for Enhancing Drug Solubility and Bioavailability

ISBN: 979-8-89881-868-5
eISBN: 979-8-89881-867-8 (Online)

Introduction

This book offers a multidisciplinary exploration of eutectic mixtures (EMs) as a strategy for overcoming poor aqueous solubility, dissolution and bioavailability of active pharmaceutical ingredients (APIs). Beginning with foundational pharmaceutical concepts, it progresses through the physicochemical, thermodynamic and solid-state fundamentals of EMs, their preparation and characterization, computational prediction of solubility behavior and applications across oral, topical, transdermal and advanced drug delivery systems.


Key Features

  • - Comprehensive coverage from drug fundamentals to industrial applications of EMs.
  • - Preparation methods: mechanical, solvent-assisted, fusion and innovative techniques.
  • - Analytical and characterization tools (DSC, TGA, PXRD, FTIR, Raman spectroscopy, microscopy).
  • - Computational approaches for predicting solubility and EM behavior.
  • - Experimental evaluation of drug release, toxicity and safety.
  • - Insights into drug coformer selection strategies.

Target Readership :

Undergraduates, postgraduates, research scholars and professors/researchers.

Contributors

Editor(s):
Kamlesh Kumari
Department of Zoology
University of Delhi
Delhi, India


Madhur Babu Singh
Vita Nova Educators Pvt. Limited
DLF Cybercity, Gurgaon
Haryana, India


Pallavi Jain
Department of Chemistry
SRM Institute of Science and Technology
NCR Campus, Ghaziabad
Uttar Pradesh, India


Prashant Singh
Department of Chemistry
Atma Ram Sanatan Dharma College
University of Delhi
Delhi, India




Contributor(s):
Anirudh Pratap Singh Raman
Department of Chemistry
Atma Ram Sanatan Dharma College, University of Delhi
Delhi
India

Department of Chemistry, Faculty of Engineering and Technology
SRM Institute of Science and Technology, NCR Campus
Ghaziabad, Uttar Pradesh
India


Auwalu Zakariyya Yau
Department of Pure and Industrial Chemistry
Bayero University
Kano
Nigeria


Devananda Devegowda
Department of Biochemistry
JSS Medical College, JSS Academy of Higher Education and Research
Mysuru, Karnataka
India


Darshna Hirpara
Department of Applied Chemistry, Faculty of Technology & Engineering
The Maharaja Sayajirao University of Baroda
Vadodara, Gujarat
India


Gandhi Mansi
Department of Chemistry
Gujarat Technological University
Ahmedabad, Gujarat
India


Himanshi Goel
Department of Chemistry
Amity Institute of Applied Sciences, Amity University
Noida, Uttar Pradesh
India


Hitesh
Department of Chemistry
Atma Ram Sanatan Dharma College, University of Delhi
Delhi
India


Ishika Rana
Department of Chemistry
Amity Institute of Applied Sciences, Amity University, Uttar Pradesh
Noida
India


Kushan Parikh
Department of Chemical Science, Faculty of Applied Sciences
Parul University
Vadodara, Gujarat
India


Kumar Rakesh Ranjan
Department of Chemistry
Amity Institute of Applied Sciences, Amity University
Noida, Uttar Pradesh
India


Lalita S. Kumar
School of Sciences, Indira Gandhi National Open University
Maidan Garhi, New Delhi
India


Manish Raj
Department of Chemistry
Rajendra College, Jai Prakash University
Chapra, Bihar
India


M. Thanmaya
Department of Microbiology
JSS Academy of Higher Education and Research
Mysuru, Karnataka
India


Mustapha Sulaiman
Department of Chemistry, College of Natural Sciences
Michigan State University
East Lansing, Michigan
USA


Mohd Aslam
Department of Chemistry
Atma Ram Sanatan Dharma College, University of Delhi
Delhi
India

Department of Chemistry, Faculty of Engineering and Technology
SRM Institute of Science and Technology, NCR Campus
Ghaziabad, Uttar Pradesh
India


Mansi Sharma
Department of Chemistry
Amity Institute of Applied Sciences, Amity University
Noida, Uttar Pradesh
India


Nisha Saxena
Department of Chemistry
M.R.M. College, L.N. Mithila University
Darbhanga, Bihar
India


Noopur Srivastava
Department of Chemistry and Biochemistry
Sharda School of Engineering & Science, Sharda University
Greater Noida, Uttar Pradesh
India


Naseer Inuwa Durumin Iya
Department of Chemistry, Faculty of Physical and Applied Sciences
Federal University
Dutse
Nigeria


Nikita Goel
Department of Chemistry
ARSD College, University of Delhi
Delhi
India


Neha Srivastava
SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology Delhi NCR Campus
Ghaziabad, Uttar Pradesh
India


Namitha Vijay
Department of Biotechnology and Bioinformatics
JSS Academy of Higher Education and Research
Mysuru, Karnataka
India


Poonam Shukla
Department of Chemistry
Veer Kunwar Singh University
Arrah, Bihar
India


Poonam Kumari
Department of Chemistry
ARSD College, University of Delhi
Delhi
India


Pallavi Jain
Department of Chemistry, Faculty of Engineering and Technology
SRM Institute of Science and Technology, NCR Campus
Ghaziabad, Uttar Pradesh
India


Prashant Singh
Department of Chemistry
Atma Ram Sanatan Dharma College, University of Delhi
Delhi
India


Priya Kumari
Department of Chemistry
Rajendra College, Jai Prakash University
Chapra, Bihar
India


R. Sindhu
Department of Biotechnology & Bioinformatics
JSS Academy of Higher Education and Research
Mysuru, Karnataka
India


Ramgopal Dhakar
Faculty of Science and Technology
Mewar University
Chittorgarh, Rajasthan
India


Ritu Sharma
Faculty of Science and Technology
Mewar University
Chittorgarh, Rajasthan
India


Rajesh Kumar
Department of Chemistry
R.D.S College, B.R.A. Bihar University
Muzaffarpur, Bihar
India


Shivangi Sharma
Department of Chemistry
Atma Ram Sanatan Dharma College, University of Delhi
New Delhi
India


Sushma Jahagirdar
Department of Biotechnology & Bioinformatics
JSS Academy of Higher Education and Research
Mysuru, Karnataka
India


Smitha S. Bhat
Department of Microbiology
JSS Academy of Higher Education and Research
Mysuru, Karnataka
India


Shashanka K. Prasad
Department of Microbiology
JSS Academy of Higher Education and Research
Mysuru, Karnataka
India


Soumya Ranjan Mishra
Centre for Nano and Material Sciences
Jain (Deemed-to-be University), Jain Global Campus
Bangalore, Karnataka
India


Sapna Raghav
Department of Chemistry
Shri Jagdishprasad Jhabarmal Tibbrewala (JJT) University
Jhunjhunu, Rajasthan
India


Sunita Bhagat
Department of Chemistry
ARSD College, University of Delhi
Delhi
India


Smriti Rana
School of Sciences, Indira Gandhi National Open University
Maidan Garhi, New Delhi
India


Sushma Jahagirdar
Department of Biotechnology and Bioinformatics
JSS Academy of Higher Education and Research
Mysuru, Karnataka, 570015
India


Smitha S. Bhat
Department of Biotechnology and Bioinformatics
JSS Academy of Higher Education and Research
Mysuru, Karnataka, 570015
India


Shashanka K. Prasad
Department of Biotechnology and Bioinformatics
JSS Academy of Higher Education and Research
Mysuru, Karnataka, 570015
India


Tanu Gupta
Department of Chemistry
Rajendra College, Jai Prakash University
Chapra, Bihar
India


Tahir A. Sulaiman
Department of Microbiology and Biotechnology
Federal University, Dutse
Dutse
Nigeria


Vishal Singh
Department of Chemistry, School of Sciences
Indira Gandhi National Open University
New Delhi
India


Vishwajit Chavda
Department of Chemistry, Institute of Science, Humanities and Liberal Studies
Indus University
Ahmedabad, Gujarat
India