Editors: Swarupananda Mukherjee, Souvik Roy, Dipanjan Karati

Molecular Targeted Therapy for Alzheimer’s Disease

eBook: US $99 Special Offer (PDF + Printed Copy): US $179
Printed Copy: US $129
Library License: US $396
ISBN: 979-8-89881-565-3 (Print)
ISBN: 979-8-89881-564-6 (Online)
Year of Publication: 2026
DOI: 10.2174/97988988156461260101

Introduction

Molecular Targeted Therapy for Alzheimer’s Disease is a comprehensive exploration of the molecular mechanisms, pathological pathways, and emerging therapeutic strategies associated with Alzheimer’s disease (AD). Positioned at the intersection of neuroscience, molecular biology, pharmacology, and biotechnology, the book focuses on targeted therapeutic approaches aimed at understanding and managing one of the world’s most complex neurodegenerative disorders.

The book systematically examines major molecular contributors to Alzheimer’s disease, including glutamate and NMDA receptor signalling, tau protein dysfunction, Axl kinase activity, NFAT dysregulation, oxidative stress, neuroinflammation, and microRNA-mediated pathways. It further explores innovative treatment strategies such as nanotechnology-based drug delivery systems, anti-amyloid antibody therapies, immunotherapy, small-molecule therapeutics, natural product-based interventions, and biopolymer-assisted treatment approaches. The concluding chapters discuss integrative molecular and targeted therapeutic frameworks that bridge current discoveries with future innovations in Alzheimer’s disease management.


Key Features

  • - Comprehensive coverage of molecular mechanisms underlying Alzheimer’s disease.
  • - Detailed discussions of targeted therapeutic and immunotherapeutic strategies.
  • - Insights into nanotechnology, small molecules, biopolymers, and natural-product-based treatments.
  • - Integration of molecular biology, pharmacology, and computational approaches focuses on emerging innovations and future directions in Alzheimer’s disease therapy.

Target Readership :

Researchers, neuroscientists, pharmacologists, clinicians, postgraduate students, and academics in neuroscience, molecular medicine, biotechnology, pharmacology, and neurodegenerative disease research.

Foreword

- Pp. i
Debasis Bagchi
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Preface

- Pp. ii
Swarupananda Mukherjee, Souvik Roy, Dipanjan Karati
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List of Contributors

- Pp. iii-v (3)

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Unveiling the Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

- Pp. 1-40 (40)
Dipanjan Karati*, Shreyasi Meur, Poulomi Sen, Swarupananda Mukherjee, Priya Ghosh

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Tau Protein in Alzheimer's Disease

- Pp. 41-61 (21)
Maitreyee Mukherjee, Soumen Dhara, Abhishek Jana, Tathagata Roy*

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Axl Kinase in Alzheimer's Disease

- Pp. 62-88 (27)
Dipanjan Karati*, Shreyasi Meur

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Role of NFAT Dysregulation in the Pathogenesis and Progression of Alzheimer’s Disease

- Pp. 89-105 (17)
Shreyasi Majumdar*, Santosh Kumar Prajapati, Puneet Samaiya, Swagata Bhattacharya, Sairam Krishnamurthy

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Pathophysiological Insights and Therapeutic Approaches of Oxidative Stress in Alzheimer’s Disease

- Pp. 106-135 (30)
Dipanjan Karati*, Tanwi Garai, Siuli Sen, Swarupananda Mukherjee, Sajal Kumar Jha, Biplab Debnath

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The Role of MicroRNAs in the Onset and Progression of Alzheimer’s Disease: An Explicative Overview

- Pp. 136-154 (19)
Sinjini Sarkar*

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Clinical Indication of the Role of Inflammation in Alzheimer’s Disease

- Pp. 155-176 (22)
Arvind Kumar*, Nilanjan Sarkar, Moumita Kundu, Vishal Singh, Debankini Dasgupta

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Nanotechnology-based Therapeutic Approach in Alzheimer's Disease

- Pp. 177-216 (40)
Rajdip Goswami, Priyanka Banerjee, Saptarshi Sanyal, Biswajit Basu*, Monosiz Rahaman

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Treatment Using Anti-Amyloid Antibodies for Alzheimer’s Disease

- Pp. 217-250 (34)
Soumyadeep Chatterjee, Sakuntala Gayen, Souvik Roy*

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Small Molecules as Anti-Alzheimer’s Scaffolds

- Pp. 251-301 (51)
Rudradeep Hazra, Souvik Roy*, Sakuntala Gayen, Ankita Parui, Amima Arshad, Nipa Roy, Asmita Nag Sarkar

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New Insights into Drug Development and Immunotherapy for Alzheimer’s Disease

- Pp. 302-337 (36)
Sakuntala Gayen, Souvik Roy*, Md Alfaj Uddin, Dishani Sukul

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Natural Products as Effective Treatment Approach for Alzheimer's Disease: In silico Justification

- Pp. 338-366 (29)
Piyali Khamkat*, Bramhajit Chatterjee, Vivek Barik, Suman Sahu, Swarupananda Mukherjee

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Biopolymer-based Therapeutic Approaches as Effective Treatment Methods for Alzheimer's Disease

- Pp. 367-406 (40)
Dipanjan Karati*, Shreyasi Meur

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Integrative Molecular Approaches in Targeted Therapy for AD: Bridging Complex Mechanisms and Future Innovations

- Pp. 407-422 (16)
Tiyas Pal, Swarupananda Mukherjee*, Dipanjan Karati, Nilanjan Pahari, Chowdhury Mobaswar Hossain, Saheli Naskar

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Subject Index

- Pp. 423-425 (3)
Swarupananda Mukherjee, Souvik Roy, Dipanjan Karati
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