Molecular Targeted Therapy for Alzheimer’s Disease

Editors: Swarupananda Mukherjee, Souvik Roy, Dipanjan Karati

Molecular Targeted Therapy for Alzheimer’s Disease

ISBN: 979-8-89881-565-3
eISBN: 979-8-89881-564-6 (Online)

Introduction

Molecular Targeted Therapy for Alzheimer’s Disease is a comprehensive exploration of the molecular mechanisms, pathological pathways, and emerging therapeutic strategies associated with Alzheimer’s disease (AD). Positioned at the intersection of neuroscience, molecular biology, pharmacology, and biotechnology, the book focuses on targeted therapeutic approaches aimed at understanding and managing one of the world’s most complex neurodegenerative disorders.

The book systematically examines major molecular contributors to Alzheimer’s disease, including glutamate and NMDA receptor signalling, tau protein dysfunction, Axl kinase activity, NFAT dysregulation, oxidative stress, neuroinflammation, and microRNA-mediated pathways. It further explores innovative treatment strategies such as nanotechnology-based drug delivery systems, anti-amyloid antibody therapies, immunotherapy, small-molecule therapeutics, natural product-based interventions, and biopolymer-assisted treatment approaches. The concluding chapters discuss integrative molecular and targeted therapeutic frameworks that bridge current discoveries with future innovations in Alzheimer’s disease management.


Key Features

  • - Comprehensive coverage of molecular mechanisms underlying Alzheimer’s disease.
  • - Detailed discussions of targeted therapeutic and immunotherapeutic strategies.
  • - Insights into nanotechnology, small molecules, biopolymers, and natural-product-based treatments.
  • - Integration of molecular biology, pharmacology, and computational approaches focuses on emerging innovations and future directions in Alzheimer’s disease therapy.

Target Readership :

Researchers, neuroscientists, pharmacologists, clinicians, postgraduate students, and academics in neuroscience, molecular medicine, biotechnology, pharmacology, and neurodegenerative disease research.

Preface

Due to the loss of mental faculties, millions of individuals worldwide are deprived of their right to cognitive freedom by Alzheimer's disease (AD), a neurodegenerative illness of exceptional magnitude. Despite significant advances in understanding and devising therapeutic management, existing medications give only limited symptom relief and fail to arrest or reverse the process of the disease. The glaring treatment barriers prompted scientists to focus on the molecular basis of Alzheimer’s, leading to the development of more accurate and possibly revolutionary approaches to treatment.

Its central goal of Molecular Targeted Therapy for Alzheimer’s Disease is to provide a thorough analysis of innovative methods of research in order to analyse and intervene into key molecular pathways of AD. The book covers a great number of key areas such as the role of amyloid-beta and tau proteins, neuroinflammation, oxidative stress, and synaptic dysfunction.

This book aims to assist researchers, clinicians, graduate students, and healthcare specialists who participate in the study of Alzheimer’s disease, which is characterized by numerous complex mechanisms. Suggesting a comprehensive review of molecular targets and associated possibilities for therapy, we enable new directions for further research and interdisciplinary collaboration in the treatment of this difficult disorder.

To all those who contributed detailed knowledge and devoted their labor to this volume, we offer our heartfelt thanks. We hope that this compilation will become an indispensable guide, an inspiration for future improvement and development in new therapeutics aiming at a molecular-level treatment for Alzheimer’s disease.

Sincerely,

Swarupananda Mukherjee
Department of Pharmaceutical Technology
NSHM Knowledge Campus – Kolkata Group of Institutions
Kolkata, West Bengal
India

Souvik Roy
Department of Pharmaceutical Technology
NSHM Knowledge Campus – Kolkata Group of Institutions
Kolkata, West Bengal
India

&

Dipanjan Karati
Department of Pharmaceutical Technology
School of Pharmacy
Techno India University
West Bengal, Kolkata
India