Editors: Prashant Kumar Dhakad, Raghav Mishra, Shweta Sharma, Sudhanshu Mishra, Nishant Gaur

Unravelling Alzheimer’s: Innovations in Pathogenesis, Diagnosis, and Therapeutics

eBook: US $119 Special Offer (PDF + Printed Copy): US $191
Printed Copy: US $131
Library License: US $476
ISBN: 979-8-89881-496-0 (Print)
ISBN: 979-8-89881-495-3 (Online)
Year of Publication: 2026
DOI: 10.2174/97988988149531260101

Introduction

Unravelling Alzheimer’s: Innovations in Pathogenesis, Diagnosis, and Therapeutics provides a comprehensive and multidisciplinary exploration of Alzheimer’s Disease (AD), one of the most pressing neurodegenerative disorders of our time.

The book examines the historical evolution, epidemiology and global impact of AD, followed by an in-depth discussion on molecular and cellular mechanisms, including amyloid-beta aggregation, tau pathology, neuroinflammation, oxidative stress, and genetic factors. It highlights advances in biomarker discovery and early detection strategies, alongside cutting-edge diagnostic technologies such as neuroimaging and AI-driven tools. Case studies and patent insights further bridge research innovation with real-world clinical application.


Key Features

  • - Comprehensive coverage of Alzheimer’s disease pathogenesis and molecular mechanisms.
  • - Detailed analysis of biomarkers for early detection and therapeutic targeting.
  • - Exploration of advanced diagnostic technologies and pharmacological advancements, including innovative drug delivery systems, neuroimaging technologies and AI-based tools.
  • - In-depth discussion on novel therapies such as immunotherapy, gene therapy, RNA-based treatments, and natural compounds.
  • - Case studies and recent developments linking research to clinical practice.
  • - Integrated perspectives combining neuroscience, pharmacology, biotechnology, and clinical medicine.

Target Readership:

Clinicians, pharmaceutical scientists, healthcare professionals, R&D specialists, and industry practitioners working in neurodegenerative disease research and drug development.

Foreword

- Pp. i
Vandana Arora Sethi
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Preface

- Pp. ii-iii (2)
Prashant Kumar Dhakad, Shweta Sharma, Sudhanshu Mishra, Nishant Gaur
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List of Contributors

- Pp. iv-vi (3)

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Introduction to Alzheimer's Disease: History, Epidemiology, and Global Impact

- Pp. 1-19 (19)
Sana Ahmad*, Sohaib Farooqui, Shafiurrahman

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Pathophysiology and Molecular Mechanisms of Alzheimer’s Disease

- Pp. 20-51 (32)
Chandragiri Siva Sai, Manish Mathur, Neha Mathur*

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Role of Biomarker in Treating Alzheimer's Disease

- Pp. 52-88 (37)
Piyush Anand, Deepak Kumar, Supriya Gupta, Juhi Tiwari, Shashi Kant Singh*

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Neuroimaging and Advanced Techniques in Alzheimer’s Diagnosis

- Pp. 89-111 (23)
Snigdha Srivastava*, Rajan Kumar Kurmi, Shiva Mishra

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Digital Tools and Artificial Intelligence in Alzheimer’s diagnosis

- Pp. 112-140 (29)
Shubh Deep Yadav, Shubhanshu Goel, Ayushi Tyagi*, Khushboo Bansal

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Natural Products and Phytochemicals in Alzheimer’s Management

- Pp. 141-176 (36)
Sakshi Tyagi*, Anubhav Tyagi, Baby Ilma, Nikhila Shekhar

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Various Immunotherapy and Targeted Therapeutics for Managing Alzheimer’s Disease

- Pp. 177-204 (28)
Mansi Verma*, Niraj Kumar Singh

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Gene Therapy and RNA-Based Innovations for Management of Alziemer's

- Pp. 205-250 (46)
Juhi Tiwari, Piyush Anand, Deepak Kumar, Shashi Kant Singh*

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Comorbidities and their Impact on Disease Progression: Focused on Alzheimer's Disease

- Pp. 251-281 (31)
Ganesh Sonawane*, Kajal Pansare, Deepak Sonawane, Chandrashekhar Patil, Sunil Mahajan

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Emerging Pharmacological Innovation in Alzheimer’s Treatment

- Pp. 282-316 (35)
Arvind Kumar Patel, Manish Singh, Shivam Kumar, Shankul Kumar, Neha Singh, Neetu Sachan, Phool Chandra

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Recent Advances in Drug Development for the Management of Alzheimer’s Disease

- Pp. 317-354 (38)
Amit Upadhyay*, Abhishek Kumar Singh, Nandani Jayaswal, Pooja Jaiswal, Shashi Kant Singh, Shashank Tewari

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Intranasal Drug Delivery in Treating Alzheimer’s Disease

- Pp. 355-389 (35)
Nitin Kumar*, Harendar Kumar Nivatya, Anjali Singh, Sonam, Lovy Sharma, Vishal Singh

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Case Studies and Patents in Alzheimer’s Disease Research

- Pp. 390-435 (46)
Deepak Kumar, Piyush Anand, Juhi Tiwari, Shashi Kant Singh*

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Subject Index

- Pp. 436-439 (4)
Prashant Kumar Dhakad, Shweta Sharma
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