Editor: Abhay Nanda Srivastva

Coordination Compounds for Pharmaceuticals and Drug Delivery Systems (Volume 1)

Volume 1

eBook: US $79 Special Offer (PDF + Printed Copy): US $135
Printed Copy: US $95
Library License: US $316
ISBN: 979-8-89881-430-4 (Print)
ISBN: 979-8-89881-429-8 (Online)
Year of Publication: 2026
DOI: 10.2174/97988988142981260101

Introduction

Coordination Compounds for Pharmaceuticals and Drug Delivery Systems explores the growing role of metal-based coordination compounds in modern pharmaceutical science. The book combines principles of coordination and medicinal chemistry with drug delivery to explain how metal complexes act as promising therapeutic, diagnostic, and theranostic agents.

It highlights the design, synthesis, and unique biological properties of coordination compounds offering innovative solutions for treating and diagnosing a wide range of diseases. The success of clinically approved metal-based drugs such as cisplatin, carboplatin, oxaliplatin, and auranofin, as well as gadolinium-based complexes used as MRI contrast agents is analysed, providing a foundation for the development of next-generation metallopharmaceuticals.

In addition to their medicinal potential, the book explores integrating coordination compounds into advanced drug delivery systems, highlighting strategies for improved targeted delivery, bioavailability, and therapeutic efficacy.


Key Features

  • - Provides comprehensive overview of coordination compounds including their design, synthesis, and biological evaluation.
  • - Discusses clinically important metal-based drugs and diagnostic agents while exploring their therapeutic applications across antibacterial, anticancer, and antidiabetic agents.
  • - Integrated perspectives on coordination and medicinal chemistry with insights into the use of coordination compounds in advanced drug delivery systems.

Target Readership :

For researchers, academics, medicinal and coordination chemists, pharmaceutical scientists and other professionals interested in metal-based therapeutics and drug delivery systems.

Preface

Chemical moieties occupied with medicinal values are the most important molecules as they cure and control many diseases to make the survival of living beings easier. Medicinal chemists always try their best to produce high quality of medicinal molecules from different branches of chemistry. Coordination compounds, among the various kinds of chemicals, have their unique importance as drug like molecules. Bioactive coordination compounds possess unique mode of drug actions due to versatility of ligands and metal ions attached together in different mode of coordination. Among the commercially available frontline drugs for curing many lethal diseases, metal based pharmaceutics like Cisplatin, Carboplatin, Oxaliplatin, Salvarsan, Auranofin, Bactiracin zinc salt etc. also cover an enough part of global pharmaceutical industries. Diagnosis capital is also roofed with Gadobutrol and Gadodiamide, Gd(III) complexes, as the commercial MRI contrasting agent. After taking an insight of these enthralled medicinal, diagnostic and theranostic appeal of metal complexes, pharmaco-researchers are focusing on the developments of potent metallic therapeutic moiety. The first volume of the book entitled “Coordination compounds for Pharmaceuticals and Drug delivery systems” is a compilation of advancements and research findings in the area of novel metal complex designing and bioactive applications from antibacterial to anticancer. An exhaustive discussion on bioactivity of metal complexes on life style generated diseases like diabetes is also focused in a chapter of the book. The advantages of coordination compounds in different drug delivery systems have also been discussed in the chapters embedded here.

I hope this compilation will be advantageous for all the personnel belonging to drug chemistry, pharmaceutical chemistry, coordination chemistry and bio-inorganic chemistry from academia to research to industries in a very simple and comprehensive style of service as a book.

Abhay Nanda Srivastva
University Department of Chemistry
Babasaheb Bhimrao Ambedkar Bihar University
Muzaffarpur, India