Editor: Rajesh Kumar

Impact of Incomplete Metabolism on Health

eBook: US $129 Special Offer (PDF + Printed Copy): US $207
Printed Copy: US $142
Library License: US $516
ISBN: 979-8-89881-250-8 (Print)
ISBN: 979-8-89881-249-2 (Online)
Year of Publication: 2025
DOI: 10.2174/97988988124921250101

Introduction

Impact of Incomplete Metabolism on Health uncovers how the buildup of toxic intermediates, enzyme deficiencies, and pathway impairments destabilize metabolic homeostasis. These disruptions contribute to chronic diseases, oxidative stress, mitochondrial dysfunction, and a wide range of cellular abnormalities.

The book begins with the fundamental principles of metabolism and then systematically explains the biochemical origins of incomplete reactions and their physiological consequences. Subsequent chapters explore metabolic syndrome, inborn errors of metabolism, and other clinically significant disorders arising from flawed metabolic pathways. The later sections delve into diagnostic strategies, therapeutic innovations, and emerging fields such as nutrigenomics, enzyme replacement therapy, and personalized metabolic medicine.

Supported by contemporary research, detailed pathway illustrations, and case-based clinical insights, this book serves as both an academic foundation and a practical guide for understanding the biochemical roots of human disease.

Key Features

  • - Clarifies the biochemical basis and clinical implications of incomplete metabolic processes.
  • - Illustrates metabolic pathways through detailed, accurate, and easy-to-understand diagrams.
  • - Connects theoretical concepts to real-world practice using case studies and clinical correlations.
  • - Integrates updated research across biochemistry, molecular biology, and clinical medicine.
  • - Explores diagnostic tools, therapeutic approaches, and emerging personalized interventions.

Target Readership:

For medical, pharmaceutical, and life science students, researchers, and clinicians studying metabolic disorders. Also valuable for nutritionists, biotechnologists, and healthcare professionals seeking deeper insight into metabolic dysfunction.

Preface

Incomplete metabolism refers to the body's inability to fully break down and process nutrients or compounds, leading to the accumulation of harmful byproducts. This can be caused by genetic factors, insufficient enzyme levels, or external influences, such as medications and certain foods. Incomplete metabolic pathways may result in the accumulation of intermediate chemicals inside tissues or the circulation, which may cause abnormal cellular activities and a range of health problems.

The metabolism of drugs is also impacted by incomplete metabolism. Some drugs can cause toxicity or adverse reactions if the liver is unable to adequately metabolize them. For instance, people with CYP2D6 deficiencies may not absorb medications like codeine or antidepressants well, which might result in either a harmful build-up or an inadequate therapeutic impact.

Chronic illnesses, including obesity, diabetes, and non-alcoholic fatty liver disease, can be brought on by environmental variables that affect metabolic pathways, in addition to hereditary problems. Examples of these factors include inadequate diet and exposure to chemicals. In general, the effects of inadequate metabolism can be extensive and severe; therefore, early detection and treatment are essential to the management of many disorders.

The book contains 10 chapters. Chapter 1 discusses the introduction to metabolism. In this chapter, the book begins with deep insights into the basics behind the metabolism and production of primary and secondary metabolites. Chapter 2 explains the understanding of incomplete metabolism. Chapter 3 tells about the metabolic pathways and intermediates produced during the various metabolic reactions. Chapters 4 and 5 explain the health implications of incomplete metabolism along with case studies of patients related to incomplete metabolism. Chapter 6 highlights the diagnostic approaches and biomarkers for the detection of metabolic disorders. Chapter 7 discusses the foundation for treatment strategies and therapeutic innovations. Both chapters 8 and 9 discuss the nutritional and lifestyle interventions along with future directions and research frontiers towards the impact of incomplete metabolism. Lastly, chapter 10 discusses the role of empowering patients and caregivers in controlling metabolic disorders.

Rajesh Kumar
Maharaja Agrasen School of Pharmacy
Maharaja Agrasen University
Solan, Himachal Pradesh, India