Editors: Ashutosh Kumar Dash, Deepak Kumar

Quinones: A Privileged Moiety for Drug Discovery

eBook: US $79 Special Offer (PDF + Printed Copy): US $127
Printed Copy: US $87
Library License: US $316
ISBN: 979-8-89881-028-3 (Print)
ISBN: 979-8-89881-027-6 (Online)
Year of Publication: 2025
DOI: 10.2174/97988988102761250101

Introduction

A multidisciplinary exploration of quinones as a vital structural class in medicinal chemistry Drawing from both natural and synthetic sources, the book explores the structural diversity, reactivity, and therapeutic potential of quinone compounds, positioning them as privileged moieties in the development of pharmacologically active agents.

The text covers essential themes such as synthesis strategies, identification techniques, biochemical relevance, and pharmacodynamics of quinones and their derivatives. It delves into their traditional use in medicine, contemporary roles in treating diseases like cancer and infections, and their capacity to interact with multiple biological targets. Specific chapters discuss glyco hybrids, ROS generation, enzymatic pathways, and toxicity profiles, offering a comprehensive overview of their medicinal versatility.

Key Features:

  • - Explores synthesis and structural modification techniques
  • - Analyzes biochemical and pharmacodynamic mechanisms
  • - Reviews traditional and modern therapeutic uses
  • - Examines toxicity concerns and safety profiles
  • - Highlights marketed drugs and emerging candidates
  • - Presents recent studies and future trends


Readership:

Students, researchers, and professionals engaged in medicinal chemistry, pharmacology, and natural product research.

Preface

- Pp. i
Ashutosh Kumar Dash, Deepak Kumar
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List of Contributors

- Pp. ii-iii (2)

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Importance of Quinones in Drug Discovery

- Pp. 1-17 (17)
Priyanku Pradip Das, Hiyashree Sharmah, Lokman Ali Ahmed, Ashutosh Kumar Dash*, Deepak Kumar*

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Chemistry and Synthesis of Quinones and their Derivatives

- Pp. 18-51 (34)
Divyani P. Patel, Satish Kumar Singh*, Vivek Mishra*

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Identification Techniques of Natural and Synthetic Quinones Using Various Methods

- Pp. 52-63 (12)
Satyanarayana Battula*, Ashutosh Kumar Dash

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Quinone in Traditional Therapy and Nutraceutical Use

- Pp. 64-86 (23)
Santosh Kumar Rath*, Ashutosh Kumar Dash

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Efficient Synthesis of Quinone-Based Glycohybrids

- Pp. 87-129 (43)
Sunil Sharma, Yogesh Yadav, Ramesh Kumar, Ram Sagar*

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Pharmacodynamics of Quinones and their Derivatives

- Pp. 130-150 (21)
Ganesh Sonawane*, Shashikant Bhandari, Ritu Gilhotra, Ashutosh Kumar Dash

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Synthetic and Natural Quinones as Drug Candidates

- Pp. 151-166 (16)
Santosh Kumar Rath*, Ashutosh Kumar Dash

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Understanding Quinones with Reference to Biochemistry

- Pp. 167-194 (28)
Adil Ali, Mohd Hasan Mujahid, Ankit Paul, Tarun Kumar Upadhyay*

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Quinone Compounds in Medicine: A Biological Perspective

- Pp. 195-227 (33)
Rajendra Dighe, Ashutosh Kumar Dash, Shashikant Bhandari, Ritu Gilhotra*

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Recent Study on Quinone Derivatives and their Applications

- Pp. 228-247 (20)
Suryakant R. Rode, Ashutosh Kumar Dash*

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Subject Index

- Pp. 248-252 (5)
Ashutosh Kumar Dash, Deepak Kumar
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