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Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases

Editors: Igor Jose dos Santos Nascimento, Ricardo Olimpio de Moura

Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases

ISBN: 978-981-5324-79-2
eISBN: 978-981-5324-78-5 (Online)

Introduction

Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseasesoffers an in-depth overview of recent progress in drug discovery targeting some of the world’s most persistent and under-researched diseases. With a focus on medicinal chemistry and target-based drug design, this book explores critical pharmacological targets and innovative compounds aimed at combating neglected tropical diseases (NTDs) and related infections.Spread across ten chapters, the book examines the current state and future directions of therapeutic research for diseases such as leishmaniasis, Chagas disease, sleeping sickness, malaria, schistosomiasis, dengue, Zika virus, tuberculosis, and fascioliasis. Each chapter provides details about disease-specific targets, structural activity relationships (SAR), and developments in promising lead compounds over the past decade.

Key Features:

  • - Focuses on pharmacological targets and medicinal chemistry strategies.
  • - Covers both parasitic and viral diseases with global health impact.
  • - Underlines emerging therapeutic approaches and SAR-guided design.
  • - Explains compound screening, optimization, and preclinical research.


Readership:

This book is intended as a key resource for both graduate and undergraduate students in pharmacy chemistry and health sciences, medicinal and pharmaceutical researchers, working professionals in the drug and biotechnology industry and healthcare professionals.

Contributors

Editor(s):
Igor Jose dos Santos Nascimento
Programa de Pós-Graduação em Ciências Farmacêuticas
Departamento de Farmácia
Universidade Estadual da Paraíba
Campina Grande-PB
Brasil


Ricardo Olimpio de Moura
Programa de Pós-Graduação em Ciências Farmacêuticas
Departamento de Farmácia
Universidade Estadual da Paraíba
Campina Grande-PB
Brasil



Contributor(s):
Arthur Gabriel Corrêa de Farias
Drug Development and Synthesis Laboratory
Department of Pharmacy, State University of Paraíba
Campina Grande 58429-500
Brazil


Adnan A. Bekhit
Department of Pharmaceutical Chemistry
Faculty of Pharmacy, Alexandria University
Alexandria 21521
Egypt
/
Pharmacy Program, Allied Health Department
College of Health and Sport Sciences, University of Bahrain
Sakhir 32038
Kingdom of Bahrain


Akankcha Gupta
Integrated Drug Discovery Research Laboratory
Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University)
Sagar (MP)
India


Aviral Kaushik
Department of Life Sciences
Parul Institute of Applied Sciences and Biophysics & Structural Biology Laboratory, Research & Development Cell, Parul University
Vadodara, Gujarat
India


Claudiu T. Supuran
Neurofarba Department, Pharmaceutical and Nutraceutical Section
University of Florence
Firenze FI, Sesto Fiorentino
Italy


C. Ratna Prabha
Department of Biochemistry
Maharaja Sayajirao University of Baroda
Vadodara, Gujarat
India


Dickson Mambwe
Department of Chemistry
School of Natural Sciences, University of Zambia
Lusaka
Zambia


Evelyn Funjika
Department of Chemistry
School of Natural Sciences, University of Zambia
Lusaka
Zambia


Éric de Oliveira Rios
Pharmacy Departament
Cesmac University Center
Maceió
Brazil


Edeildo Ferreira da Silva-Júnior
Research Group on Biological and Molecular Chemistry
Institute of Chemistry and Biotechnology, Federal University of Alagoas
Lourival Melo Mota Avenue, 57072-970, Maceió
Brazil


Fabrizio Carta
Neurofarba Department, Pharmaceutical and Nutraceutical Section
University of Florence
Firenze FI, Sesto Fiorentino
Italy


Gioele Renzi
Neurofarba Department, Pharmaceutical and Nutraceutical Section
University of Florence
Firenze FI, Sesto Fiorentino
Italy


Godfrey Mayoka
Department of Pharmacology and Pharmacognosy
School of Pharmacy, Jomo Kenyatta University of Agriculture and Technology
Nairobi
Kenya


Gourav Rakshit
Department of Pharmaceutical Sciences & Technology
Birla Institute of Technology
Mesra, Ranchi, JH
India


Igor José dos Santos Nascimento
Pharmacy Department
State University of Paraíba
Campina Grande
Brazil
/
Drug Development and Synthesis Laboratory
Department of Pharmacy, State University of Paraíba
Campina Grande 58429-500
Brazil
/
Pharmacy Departament
Cesmac University Center
Maceió
Brazil


Ileana Corvo
Laboratorio de I+D de Moléculas Bioactivas
Departamento de Ciencias Biológicas, Centro Universitario Regional Litoral Norte
Universidad de la República, Paysandú
Uruguay


Karla Joane da Silva Menezes
Pharmacy Department
State University of Paraíba
Campina Grande
Brazil
/
Drug Development and Synthesis Laboratory
Department of Pharmacy, State University of Paraíba
Campina Grande 58429-500
Brazil


Krupanshi Bharadava
Department of Life Sciences
Parul Institute of Applied Sciences and Biophysics & Structural Biology Laboratory, Research & Development Cell, Parul University
Vadodara, Gujarat
India


Leandro Rocha Silva
Research Group on Biological and Molecular Chemistry
Institute of Chemistry and Biotechnology, Federal University of Alagoas
Lourival Melo Mota Avenue, 57072-970, Maceió
Brazil


Marianny de Souza
Pharmacy Departament
Cesmac University Center
Maceió
Brazil


Mohamed Teleb
Department of Pharmaceutical Chemistry
Faculty of Pharmacy, Alexandria University
Alexandria 21521
Egypt


Mohd Usman Mohd Siddique
Department of Pharmacy
SVKM’s Institute of Pharmacy
Dhule, MH
India


Mitali Mishra
Integrated Drug Discovery Research Laboratory
Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University)
Sagar (MP)
India


Mauricio Cabrera
Laboratorio de I+D de Moléculas Bioactivas
Departamento de Ciencias Biológicas, Centro Universitario Regional Litoral Norte
Universidad de la República, Paysandú
Uruguay


Nigam Vyas
Department of Microbiology
Parul Institute of Applied Sciences, Parul University
Vadodara, Gujarat
India
/
Department of Life Sciences
Parul Institute of Applied Sciences and Biophysics & Structural Biology Laboratory, Research & Development Cell, Parul University
Vadodara, Gujarat
India


Peter Mubanga Cheuka
Department of Chemistry
School of Natural Sciences, University of Zambia
Lusaka
Zambia


Priyanshu Nema
Integrated Drug Discovery Research Laboratory
Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University)
Sagar (MP)
India


Ricardo Olimpio de Moura
Pharmacy Department
State University of Paraíba
Campina Grande
Brazil
/
Drug Development and Synthesis Laboratory
Department of Pharmacy, State University of Paraíba
Campina Grande 58429-500
Brazil


Rajendra Prasad Chatterjee
National Institute of Cholera and Enteric Diseases
Indian Council of Medical Research
Kolkata, WB
India


Radhey Shyam Kaushal
Department of Life Sciences
Parul Institute of Applied Sciences and Biophysics & Structural Biology Laboratory, Research & Development Cell, Parul University
Vadodara, Gujarat
India


Salma Darwish
Department of Pharmaceutical Chemistry
Faculty of Pharmacy, Alexandria University
Alexandria 21521
Egypt


Sherry N. Nasralla
Pharmacy Program, Allied Health Department
College of Health and Sport Sciences, University of Bahrain
Sakhir 32038
Kingdom of Bahrain


Sherine N. Khattab
Chemistry Department
Faculty of Science, Alexandria University
Alexandria 21321
Egypt


Silvia Selleri
Neurofarba Department, Pharmaceutical and Nutraceutical Section
University of Florence
Firenze FI, Sesto Fiorentino
Italy


Sheikh Murtuja
Department of Pharmaceutical Technology
School of Health and Medical Science, Adamas University
Kolkata, WB
India


Shilpa Chatterjee
Department of Pharmaceutical Technology
School of Health and Medical Science, Adamas University
Kolkata, WB
India


Samyak Bajaj
Integrated Drug Discovery Research Laboratory
Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University)
Sagar (MP)
India


Sushil Kumar Kashaw
Integrated Drug Discovery Research Laboratory
Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University)
Sagar (MP)
India


Tarun Kumar Upadhyay
Department of Life Sciences
Parul Institute of Applied Sciences and Immuno-biochemistry Laboratory, Research & Development Cell, Parul University
Vadodara, Gujarat
India



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