Introduction

With renal dysfunction affecting millions worldwide, this book presents a timely and integrative look at emerging insights—from molecular foundations to clinical management. It explores the intricate mechanisms, systemic impact, and clinical complexities of kidney diseases in a multidisciplinary context.

Spanning a broad spectrum of conditions, the book addresses renal tubular acidosis, polycystic kidney disease, renal lithiasis, diabetic kidney disease, and sodium imbalance–linked hypertension. Chapters delve into nephrotoxicity, loss of cellular identity in renal carcinoma, epigenetics, dysbiosis, and the evolving role of SGLT2 inhibitors. The book also highlights innovative approaches such as stem cell therapy and the systemic immune interactions that underlie chronic kidney injury.

Key Features:

• - Examines genetic and epigenetic underpinnings of renal disease
• - Explores microbiota and immune system crosstalk in kidney pathology
• - Discusses both acute and chronic conditions with clinical relevance
• - Integrates foundational science with translational perspectives
• - Includes emerging therapies and precision medicine approaches

Readership:

Nephrologists, researchers, clinicians, and graduate students aiming to gain a comprehensive view of renal disease mechanisms and deeper understanding of kidney dysfunction in both localized and systemic contexts.