Author: Y. Robert Li

Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies

eBook: US $129 Special Offer (PDF + Printed Copy): US $240
Printed Copy: US $175
Library License: US $516
ISBN: 978-1-60805-530-2 (Print)
ISBN: 978-1-60805-322-3 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080532231120101

Introduction

Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including cardiovascular diseases, diabetes and metabolic syndrome, neurological disorders, and cancer among many others. This peer-reviewed E-book covers both the fundamental principles and the recent advances in free radical biomedicine along with in-depth discussions of the clinical correlations. It also provides a thorough coverage of the commonly used methods in free radical and antioxidant research with detailed schematic illustrations as well as succinct descriptions of the procedures. This volume should also be a valuable source of information for readers who wish to gain a sound understanding of the research methodologies in this rapidly evolving field.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

Preface

The last two to three decades have witnessed the remarkable advances in our knowledge about free radicals and related reactive species, especially reactive oxygen and nitrogen species (ROS/RNS) in biomedicine. It has been increasingly recognized that ROS/RNS play an important role in the pathophysiology of diverse diseases, including cardiovascular diseases, diabetes and metabolic syndrome, neurological disorders, and cancer among many others. In agreement with this notion, substantial studies have demonstrated the effectiveness of various antioxidant-based modalities in disease intervention. New knowledge in free radical biomedicine will certainly further increase our ability to develop more effective mechanistically-based strategies to combat human diseases that involve a free radical-mediated pathophysiological component.

This book integrates knowledge in free radical biomedicine from essentials to advances, and from basic research to clinical correlations. It also covers basic and advanced methodologies in free radical research. It is hoped that the book will provide the reader a unique approach to understanding the rapidly evolving field of free radical biomedicine.

This book would not have been possible without the assistance of my son Jason Z. Li who drew all the chemical structures for the whole book, and my wife H. Zhu, MD for her critical review of the entire book manuscript. I am grateful to those (over 100 scientists worldwide) who provided me reprints of their publications and/or expertly reviewed part of the book manuscript. I am thankful for the time and effort made by the editorial personnel, especially Ms. Sarah Khan at Bentham Science Publishers, and the constructive suggestions resulting from the outside peer-review of the entire book manuscript sponsored by Bentham Science Publishers.

Y. Robert Li, MD, MPH, PhD
Virginia Tech Corporate
Research Center
Blacksburg
Virginia
USA
yli@vcom.vt.edu